Gibson Lopez (34) and Kevin Bawa (35), who managed the pub at Kamala Mills compound in Lower Parel, were arrested by policemen from the N M Joshi Marg police station, he said.
The managers were present in the pub when the blaze swirled over its terrace in the early hours of December 29, but they fled without helping the guests, the official said.
They have been booked under various sections of the IPC for culpable homicide not amounting to murder, causing hurt by an act endangering life of others, causing grievous hurt by act endangering life or safety of others and acts done by several persons in furtherance of common intention, he said.
The two were produced in a local court, which remanded them to police custody till January 9, the official said.
However, the main accused in the case were still at large. The police has sent teams across Maharashtra - and also outside the state - to trace them, he said.
The massive fire that swept through the pub killed 14 people and 21 injured.
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