She did not indicate which ministers are set to lose their jobs. The Sunday Times reported that several senior ministers will stay in their posts, including Foreign Secretary Boris Johnson and Brexit Secretary David Davis.
May's grip on power was weakened by her Conservative Party's poor showing in a June election, which saw it reduced to a minority government.
But the embattled British leader got a boost last month when the European Union agreed that talks on the U.K.'s departure had made enough progress to start discussing future trade relations.
May told the BBC in an interview broadcast Sunday that she hoped to secure agreement with the EU on a post-Brexit transition period by March 31, and to draft a withdrawal agreement by the end of 2018.
Britain is due to leave the EU on March 29, 2019. May's chances of staying in power depend heavily on her ability to secure a smooth exit and a good free-trade deal with the bloc.
"I'm not a quitter. I'm in this for the long term," May said.
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