Guterres this week spoke out in defence of the Iran nuclear deal that Trump has refused to certify, describing the 2015 agreement as "essential" and "something that needs to be preserved."
The fate of the deal is now in the hands of the US Congress.
It will be the UN chief's first full formal meeting with Trump at the White House after a brief encounter with the US president in April.
Guterres held a bilateral meeting with Trump during the UN General Assembly session in New York last month during which the US president also led a high-level meeting on UN reform.
UN spokesman Stephane Dujarric said UN reform would be discussed along with "issues of mutual concern", but did not provide details.
UN sources said they expected the Middle East peace process, North Korea, the Iran nuclear deal to be among the issues raised.
The United States is the biggest financial contributor to the United Nations, providing 22 percent of its $5.4 billion core budget and 28 percent of its $7.3 billion peacekeeping budget.
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