The agreement will step up joint actions to combat air pollution, climate change and anti-microbial resistance, as well as improve coordination on waste and chemicals management, water quality, and food and nutrition issues.
Erik Solheim, head of UN Environment, and Tedros Adhanom Ghebreyesus, director general of WHO, signed the agreement in Nairobi, according to a WHO statement released in New Delhi.
The collaboration also includes joint management of the 'BreatheLife' advocacy campaign to reduce air pollution for multiple climate, environment and health benefits.
This represents the most significant formal agreement on joint action across the spectrum of environment and health issues in more than 15 years.
"Our health is directly related to the health of the environment we live in. Together, air, water and chemical hazards kill more than 12.6 million people a year. This must not continue," Tedros said.
"Most of these deaths occur in developing countries in Asia, Africa and Latin America where environmental pollution takes its biggest health toll," he added.
"The two agencies will develop a joint work programme and hold an annual high-level meeting to evaluate progress and make recommendations for continued collaboration," it said.
The priority areas of cooperation between WHO and UN Environment include more effective air quality monitoring, including guidance to countries on standard operating procedures, more accurate environment and health assessments, including economic assessment among others.
On the climate front, it would give priority to tackling vector-borne disease and other climate-related health risks.
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