Virginia Gamba stressed that the team of 24 multi-skilled experts she is assembling will adhere to "sound, objective, impartial" guidelines "that no one can question" to find the culprits.
"Will I have the name, surname, and age of a perpetrator? I have no idea," Gamba told AFP in an interview at her new UN offices. "It's going to be very hard to do."
Describing herself as a "technician," Gamba was picked for the job partly because she has worked on two previous UN missions on chemical weapons use in Syria.
But this panel is "a different kettle of fish," she stressed, with a broader scope and more challenging mandate to identify who is to blame for the attacks, using unassailable methodology.
The starting point for the international investigation are three fact-finding missions from the Organization for the Prohibition of Chemical Weapons that concluded that chlorine was probably used as a weapon on the opposition-held villages, killing 13 people.
Taking those reports, the panel has been asked to dig deeper with the aim of not only pointing the finger at those who carried out the attacks, but also identifying their co-conspirators, organizers, financial backers and sponsors.
"This is what the intention is: to create a very big canvas where everyone would be accountable either directly or indirectly from the very first round of accountability to the end," said the 61-year-old former head of the UN disarmament agency.
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