The drone fired two missiles at a compound in a village of Shawal sub-division of North Waziristan Agency late tonight.
The compound was destroyed in the attack, security officials were quoted as saying by TV news channels.
A "high value target" was among those killed in the attack, a report on the website of the Dawn newspaper quoted intelligence sources as saying.
It did not give details.
Shortly after being elected Prime Minister by the lower house of parliament on Wednesday, Sharif had said the attacks by US drones in Pakistan's tribal belt should stop.
He described the attacks as a violation of the country's sovereignty.
The strikes by the CIA-operated spy planes are criticised by the Pakistan government as counter-productive for the war on terror.
US officials say the drones are a vital weapon in the campaign against militants.
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