The drone strike took place in Lawra Mandi area of Datta Khel in the North Waziristan tribal district bordering Afghanistan, where the Pakistani military is battling Taliban militants.
"At least five militants were killed in a drone attack," a senior security official told AFP.
Another security official in Peshawar confirmed the attack and casualties.
North Waziristan is one of seven semi-autonomous tribal districts that border Afghanistan. It has been a hub for Al-Qaeda and Taliban militants since the early 2000s.
Washington pressed Islamabad for years to wipe out militant sanctuaries in North Waziristan, which groups have used to launch attacks on NATO forces in Afghanistan.
Pakistan began a long-awaited push to clear insurgent bases from North Waziristan last June after a bloody Taliban attack on Karachi airport sank faltering peace talks.
The army has intensified its offensive since the Taliban's massacre of 153 people, mostly children, in a school in the northwestern city of Peshawar in December.
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