"You pick and choose your battles," Nikki Haley told reporters. "And when we're looking at this it's about changing up priorities and our priority is no longer to sit and focus on getting Assad out."
Haley was speaking after US Secretary of State Rex Tillerson had signalled a change in the US stance by admitting that Assad's eventual fate was up to the Syrian people.
Speaking at the US mission to the United Nations, which is about to assume the rotating presidency of the UN Security Council, Haley said Washington will focus on the push for a political solution.
"We can't necessarily focus on Assad the way the previous administration maybe did. Do we think he's a hindrance? Yes," she said.
"Are we going to sit there and focus on getting him out? No."
Haley said she would focus on ways to remove the influence of Assad's ally Iran, which has supported him in his civil war against rebel forces.
And she said Washington would work with other players in the conflict, including Turkey, to seek a long term solution.
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