Kyrgyzstan hosts a US base that is used for troops transiting into and out of Afghanistan and for C-135 tanker planes that refuel warplanes in flight.
A ministry official who did not give his name said the plane crashed today afternoon near the village of Chaldovar, about 100 miles (160 kms) west of the base.
The head of the region that includes Chaldovar, Kuralbek Khamaliyev, told The Associated Press by telephone that the plane broke into three pieces when it crashed into an uninhabited area.