The brilliant 19-year-old scored one and made another to cap a sensational 19-minute burst at the start of this crucial World Cup qualifier to see off a shellshocked Panama team and help the US take a firm step towards next year's finals.
Pulisic opened the scoring on eight minutes and beautifully set up strike partner Jozy Altidore to make it two and compound a nightmare start for Panama, who now look destined to settle for a play-off match against either Syria or Australia to land a World Cup place for the first time in their history.
For the Americans, however, a win against bottom of the hexagonal table Trinidad and Tobago on Tuesday will seal their ticket for an eighth consecutive finals and even a point should do it.
"It was a good win for our team," US manager Bruce Arena said. "We have had a great year despite what people think. We have come a long way.
"The game in Trinidad won't be easy but we are in a good position now. It will be challenging. We faced challenging conditions in Honduras and Panama so we will be ready. Trinidad are out but will be a handful."
And with Panama arriving in Orlando a point ahead of the US and eyeing an historic trip to the finals, the tension was palpable.
The last four matches between the two had all ended in draws, a result which would have suited Hernan Dario Gomez's side, who close out qualifying next week against a Costa Rican side who should have joined Mexico in qualifying by then.
Pulisic, who has now been involved in 11 of his side's 16 goals in this entire qualifying run - had the kind of youthful, skillful exuberance needed to unlock the most miserly of backlines.
Bobby Wood, who was given the start ahead of veteran Clint Dempsey, led the line with Altidore.
And it was the former Sunderland striker who went close early on when his close range shot was charged down before Wood shot inches wide soon after.
His wastefulness was to prove key as Pulisic produced some brilliance to settle US nerves.
Strike partner Altidore flicked the ball on and after the Dortmund star escaped the challenge of Roman Torres, he calmly rounded Jaime Penedo and slid home from a tight angle.
"At some point people are going to stop talking about his age and start talking about what a good player he is," teammate Michael Bradley said of Pulisic.
Pulisic's contribution on 19 minutes was equally impressive.
The US were utterly dominant and on 43 minutes the game was put to bed. Wood was tripped in the area by substitute Armando Cooper and Altidore stepped up and cheekily chipped the ball down the middle.
"We wanted to press them early and get behind their backline," Arena said.
"Christian's first goal was a terrific finish and I was pleased for both Jozy and Bobby Wood. Our top three attackers all had a good night."
Pulisic left the field to rapturous applause on 56 minutes and the house was brought down yet again on 63 minutes as Wood capped an industrious performance with a well taken strike.
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