Massachusetts law requires protesters to stay at least 35 feet (10 meters) from the entrances to clinics that provide abortions and today's ruling could have implications for other US states that have similar "buffer" legislation.
The high court ruled unanimously that the 2007 Massachusetts restriction "violates the First Amendment" of the US Constitution, which ensures freedom of expression.
The law, the court said in a decision written by Chief Justice John Roberts, "restricts access to 'public way[s]' and 'sidewalk[s],' places that have traditionally been open for speech activities."
But at the same time, it said, "they impose serious burdens on petitioners' speech, depriving them of their two primary methods of communicating with arriving patients: close, personal conversations and distribution of literature."
Seven anti-abortion advocates led by plaintiff Eleanor McCullen appealed the case to the Supreme Court.
Anti-abortion advocates have set up long-running protests outside many abortion clinics.
In some instances demonstrators have brandished pictures of aborted fetuses, handed out informational pamphlets and suggested alternatives to abortions to women arriving at clinics.
Two doctors who provided abortions were killed in 1994 in Massachusetts.
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