Mandela, who turns 95 next month, was taken to a Pretoria hospital for his fourth hospital stay in seven months. A spokesman said he was in "serious but stable" condition.
"Our thoughts and prayers are with him, his family and the people of South Africa as he recovers," US National Security Council spokeswoman Caitlin Hayden said.
President Barack Obama, who has often called Mandela an inspirational figure, was concluding two days of informal talks with his Chinese counterpart Xi Jinping in California.
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