The violence comes after rebel chief Abdulmalik al-Huthi vowed to step up protests and with Saudi Arabia accusing rebels of "conspiring" to destabilise Yemen.
Activists have been camped out in the capital for weeks in a campaign to bring down the government and secure greater representation in state institutions.
Thousands of the Huthi rebel activists blocked main thoroughfares in central Sanaa today, with some of them marching on government headquarters, witnesses said.
In a statement on the official Saba news agency, an interior ministry official confirmed that police had stopped protesters, who "tried to storm... The premises of the council of ministers."
AFP could not independently verify the Huthi toll.
Later in the afternoon, troops prevented a Huthi vehicle loaded with arms from entering the capital, sparking a clash in Hiziaz, a southern entrance to Sanaa, a security official said.
An army officer was wounded, the official told AFP.
Saba quoted the high commission for security as saying, without giving details, that a number of guards were hit by gunfire from the attackers, and the health ministry said an ambulance driver was killed.
On Sunday, the rebels said two demonstrators were shot dead and around 40 wounded in clashes with police special forces near the interior ministry, where the rebels have been expanding their sit-in and blocking a main road leading to the airport.
Huthi protesters have forced shut the ministries of electricity and telecommunications and rebels yesterday prevented government vehicles from entering or leaving the capital.
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