The accident took place at around 6:50 p.m. yesterday in Suizhou City of Hubei, the city government said.
The bus was travelling from Shanghai to Chengdu, capital of southwest China's Sichuan Province. The bus was carrying 46 people.
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Fatal road accidents are a serious problem in China, where traffic regulations are often flouted.
The country's frequently overcrowded long-distance buses are prone to accidents, with individual incidents regularly causing many deaths.
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