Such protests occur every year outside the former embassy compound to mark the anniversary of the 1979 takeover following the Islamic Revolution. But the latest demonstration is the largest in years after calls by groups such as the powerful Revolutionary Guard for a major showing, including chants of "death to America" that some of Rouhani's backers have urged halted.
The crowds also send a message to Iran's Supreme Leader Ayatollah Ali Khamenei, who cautiously has backed Rouhani's overtures to the US and efforts to end the impasse with the West over Tehran's nuclear programme.
Opponents of thawing relations with the US say they will not back down, opening the prospect of deeper internal rifts and tensions that could put pressure on Khamenei to reconsider his backing of Rouhani's groundbreaking exchanges with the US.
In September, Rouhani accepted from a call from US President Barack Obama following the annual UN General Assembly in New York, where US Secretary of State John Kerry held talks with Iran's foreign minister. Ties between the two countries were severed after the embassy siege, which began a hostage crisis with 52 people held for 444 days.
Critics of the dialogue made their views immediately known, hurling insults and eggs at Rouhani's entourage upon their return from New York. Late last month, huge banners appeared around Tehran depicting the US as a sinister and deceitful adversary that seeks to weaken Iran. Tehran officials ordered the signs removed, but they appeared in poster form at the demonstration today outside the former embassy compound.
Protesters also stomped on images of Obama and the US flag.
Yesterday, Khamenei appeared to chide hard-liners by denouncing any attempts to undermine Iran's nuclear negotiators. Talks with world powers are scheduled to resume Thursday in Geneva.
Diplomats "are on a difficult mission and nobody should weaken those who are on assignment," the official IRNA news agency quoted Khamenei, who has final say on all matters of state, as telling a group of students.
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