The explosion took place just as the vehicle was due to leave a bus terminal at Quetta's Saryab Road yesterday night.
Officials said most of those killed were daily wage labourers, adding that 8 of the injured were in a critical condition.
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"It was meant to cause maximum damage and casualties as this is the last bus to leave the terminal everyday," Khan said.
Police surgeon Dr Noor Baloch told PTI over telephone that most of the deceased were sitting in the back seats or on the roof of the bus and were killed immediately.
"The dead include two children while eight passengers who were brought to the hospital are in a critical condition," he said.
The explosion took place at a bus terminal in Dukani Baba Chowk area on the main Saryab Road, rescue officials said.
The registration number of the bus was confirmed as BSA-348.
Rescue personnel said that two children were among the dead. "Most of those killed are daily wage labourers who come to Quetta to work on daily basis," one rescue official added.
Balochistan Chief Minister, Dr Malik Baloch, strongly condemned the bombing and termed it "a conspiracy against durable peace in Balochistan".
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