The losses, which picked up late in the session after the S&P 500 briefly traded in positive territory, followed a steep selloff late last week tied to emerging market concerns. The slide gave the S&P 500 its worst weekly percentage loss since June 2012.
Caterpillar Inc, however, limited the losses of the Dow and S&P 500. The stock jumped 5.9% to $91.29 after the maker of mining and construction equipment reported a stronger-than-expected quarterly profit.
The technology sector led the day's decline, with the S&P 500 technology sector index falling 1% and the Nasdaq underperforming both the Dow and S&P 500. Google , off 2% at $1,101.23, and Microsoft , down 2.1% at $36.03, were among the day's biggest drags.
After the bell, shares of Apple fell 5.7% to $519.38 after its results showed iPhone holiday sales lagged Wall Street's expectations.
"There's still a lot of nervous money hanging around," said Bucky Hellwig, senior vice president of BB&T Wealth Management in Birmingham, Alabama.
"The Fed is meeting this week, and the consensus is they're going to proceed with the taper."
The Fed's two-day policy meeting begins on Tuesday. Many market participants are bracing for the market to sell off if the Fed decides to keep withdrawing stimulus. In December, the US central bank announced plans to begin scaling back its massive bond-buying program.
The Dow Jones industrial average fell 41.23 points or 0.26%, to end at 15,837.88. For the Dow, Monday marked a fifth session of losses.
The S&P 500 dropped 8.73 points or 0.49%, to finish at 1,781.56. The Nasdaq Composite slid 44.56 points or 1.08%, to close at 4,083.61.
Last week's heavy selling raised some concerns that the market may be in for a major correction, especially with the S&P 500 closing on Friday below its 50-day moving average for the first time since October 9 and falling further below that level on Monday. The Nasdaq also ended below its 50-day moving average on Monday.
In another indicator of possible market direction, the Dow Jones Transportation Average ended down 0.8% after dropping 4.1% on Friday, its biggest decline since September 2011.
Some did not consider the recent selling as cause for concern.
"The slowdown in emerging markets isn't prevalent enough to derail the deepening economic recovery that we're seeing across developed markets," said Steven Rees, US head of equity strategy at J P Morgan Private Bank in New York.
"We're not expecting a major correction in the market this year."
Another dampener on Monday's sentiment was data showing sales of new US single-family homes fell more than expected in December, even though lean inventories and steady price gains suggested sufficient strength in the housing market.
But Caterpillar was the latest major company to beat on bottom-line results. Caterpillar's cost cuts and an uptick in demand for building equipment offset weak sales to the mining industry.
S&P 500 earnings for the fourth quarter are now expected to have increased 8% from a year ago, with 66.7% of results so far beating analysts' profit expectations, Thomson Reuters data showed. Revenue growth for the quarter is estimated at just 0.5%.
Volume was above average for the month. About 8 billion shares changed hands on US exchanges, compared with the average of 6.8 billion so far this month, according to data from BATS Global Markets.
Decliners outnumbered advancers on the New York Stock Exchange by about 3 to 1. On the Nasdaq, more than three stocks fell for every one that rose.
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