In its report, the Amnesty International (AI) also expressed concern that "some officials and institutions" in Pakistan and in other countries including Australia, Germany and the UK may be assisting the US to carry out drone strikes that constitute human rights violations.
The report, "'Will I be next?' US drone strikes in Pakistan", has said a number of civilians were killed in US drone strikes in Pakistan.
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"Amnesty International is not in a position to endorse these figures, but according to these sources, between 400 and 900 civilians have been killed in these attacks and at least 600 people seriously injured," it said.
The US has maintained that the drone strikes are targeted at specific terrorists. However, Pakistani government and rights groups have said there is a lot of collateral damage.
"Secrecy surrounding the drones program gives the US administration a license to kill beyond the reach of the courts or basic standards of international law.
"It's time for the USA to come clean about the drones program and hold those responsible for these violations to account," said Mustafa Qadri, AI's Pakistan Researcher.
AI said it reviewed all 45 known drone strikes that took place in North Waziristan in northwestern Pakistan between January 2012 and August 2013. The region that has seen more strikes than any other part of the country.
It said detailed field research into nine of these strikes, with the report documenting killings, raise serious questions about violations of international law that could amount to war crimes or extrajudicial executions.
Giving details of civilian casualties, the rights group said in October 2012, 68-year-old grandmother Mamana Bibi was killed in a double strike, apparently by a Hellfire missile, as she picked vegetables in the family's fields while surrounded by a handful of her grandchildren.
In July 2012, 18 laborers, including a 14-year-old boy, were killed in multiple strikes on a impoverished village close to the border with Afghanistan as they were about to enjoy an evening meal at the end of a long day of work.
Missiles first struck a tent in which some men had gathered for an evening meal after a hard day's work, and then struck those who came to help the injured from the first strike.
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