The Nikkei share average was down 0.4% to 27,027.51 by 0211 GMT, after falling as much as 1% to its lowest since December 2020. The broader Topix edged down 0.1% to 1,894.60.
The Fed is due to update its policy plan, likely fleshing out timing on expected rate hikes and shrinking its massive balance sheet.
"Looking at the sell-off today, the market is expecting a hawkish move and the point is how hawkish the Fed will be." Technology heavyweights fell, with chip making equipment maker Tokyo Electron losing 1.35%, robot maker Fanuc falling 3.58% and motor maker Nidec slipping 3.75%.
Toyota Motor fell 1.05%, giving up gains fuelled by the auto maker's plans to produce a record 11 million cars in fiscal 2022.
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