Spot gold was unchanged at $1,797.71 per ounce by 0532 GMT. U.S. gold futures was up 0.2% at $1,798.80.
Traders in the Fed funds futures market moved to price in nearly five rate hikes this year in the wake of Powell's remarks on Wednesday, starting with the March meeting.
Futures have factored in about 30 basis points of tightening.
The U.S. two-year yield, which reflects interest rate expectations, surged to 1.208% on Thursday, a nearly two-year peak.
Gold prices will drift lower in 2022 and 2023, as central banks raise interest rates, a Reuters poll showed.
Spot gold may retest a support at $1,792 per ounce, a break below which could cause a fall to $1,777, according to Reuters technical analyst Wang Tao.
Spot silver was up 0.2% to $22.79 an ounce. Platinum rose 0.6% to $1,028.36 and palladium fell 0.8% to $2,356.20.
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