BMI has no role in CVD risk in metabolically healthy women

Metabolically healthy women have same cardiovascular disease risk regardless of their having different BMIs, according to a study.

Dr Soren Skott Andersen and Dr Michelle Schmiegelow from Denmark findings in more than 260,000 subjects suggest that obese women have a window of opportunity to lose weight and avoid developing a metabolic disorder, which would increase their CVD risk.

The study used Danish national health databases and followed 261,489 women who had given birth during 2004-2009 with no prior history of cardiovascular disease. The women were divided into four categories according to their pre-pregnancy body mass index (BMI, kg/m2) and presence of metabolic disorders (present/not present). The women's mean age was 31 years.

The women were followed for an average of 5 years following childbirth. Discharge diagnoses and data on cause of death were used to determine if the women had a heart attack, a stroke, or died.

The researchers found that being overweight (BMI=25 kg/m2) but metabolically healthy was not associated with an increased risk of a heart attack, stroke or a combination of heart attack/stroke/death in comparison with normal weight, metabolically healthy women.

The investigators found that the metabolically unhealthy, overweight women had an almost 7-fold increased risk of heart attack and a 4-fold increased risk of stroke.