Maternal smoking linked to asthma in third generation offspring

A new study led by an Indian researcher found for the first time that maternal smoking can cause the third generation of offspring to suffer from the chronic lung disease.

The study, by Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) researchers, reported that maternal nicotine exposure during pregnancy is linked to asthma in the third generation in disease models.

This is known as a "transgenerational" linkage because the third generation was never directly exposed to nicotine or smoking.

Previous research had found nicotine exposure was linked to asthma in the second generation, or was a "multigenerational" cause of asthma.

"Even though there are multiple causes for childhood asthma, research linking this serious chronic condition to maternal nicotine exposure during pregnancy for up to three generations should give mothers-to-be even more reasons to reconsider smoking," Virender K. Rehan, MD, an LA BioMed lead researcher and the corresponding author of the study, said.

"Eliminating the use of tobacco during pregnancy could help halt the rise in childhood asthma and ensure healthier children for generations to come," he said.

Worldwide, approximately 250 million women smoke daily, and the number of people living with asthma is expected to grow by about a third by 2025, reaching approximately 400 million.

Twelve percent of women in the US continue to smoke during pregnancy, resulting in the birth of at least 400,000 smoke-exposed infants per year in the US alone.

The study is published online by the American Journal of Physiology - Lung Cellular and Molecular Physiology.