Silent strokes common than overt ones in older patients: study

In a recent study, researchers have explored silent covert strokes that are common than overt strokes in people aged around 65 and have undergone surgery.

The study was published in the journal, 'The Lancet'.

While an overt stroke causes symptoms such as weakness in one arm or speech problems that last more than a day, a covert stroke is not obvious except on brain scans, such as MRI.

According to researchers, each year, approximately 0.5 per cent of the 50 million people aged 65 years or older worldwide who have major, non-cardiac surgery will suffer an overt stroke, but until now little was known about the incidence or impacts of silent stroke after surgery.

Dr PJ Devereaux, co-principal investigator of the NeuroVISION study said, "We've found that 'silent' covert strokes are actually more common than overt strokes in people aged 65 or older who have surgery."

The principal investigator along with his team found that one in 14 people over age 65 who had elective, non-cardiac surgery had a silent stroke, suggesting that as many as three million people in this age category globally suffer a covert stroke after surgery each year.

I order to understand the study well, the researchers at NeuroVISION involved 1,114 patients aged 65 years and older from 12 centres in North and South America, Asia, New Zealand, and Europe. All patients received an MRI within nine days of their surgery to look for imaging evidence of silent stroke.

The research team followed patients for one year after their surgery to assess their cognitive capabilities. They found that people who had a silent stroke after surgery were more likely to experience cognitive decline, perioperative delirium, overt stroke or transient ischaemic attack within one year, compared to patients who did not have a silent stroke.

"Over the last century, surgery has greatly improved the health and the quality of life of patients around the world. Surgeons are now able to operate on older and sicker patients thanks to improvements in surgical and anaesthetic techniques. Despite the benefits of surgery, we also need to understand the risks," said Dr Marko Mrkobrada, an associate professor of medicine at the University of Western Ontario and co-principal investigator for the NeuroVISION study.

"Vascular brain injuries, both overt and covert, are more frequently being detected, recognized and prevented through research funded by our Institute and CIHR. The NeuroVISION Study provides important insights into the development of vascular brain injury after surgery and adds to the mounting evidence of the importance of vascular health on cognitive decline," said Dr Brian Rowe, scientific director of the Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research (CIHR).

"The results of NeuroVISION are important and represent a meaningful discovery that will facilitate tackling the issue of cognitive decline after surgery," he concluded.