Several of those injured are in critical condition, the Las Vegas Metropolitan Police Department said.
The incident occurred yesterday, on same night that Las Vegas was hosting the Miss Universe pageant, which saw the crowning of Miss Philippines.
"Over 37 injured in crash on Las Vegas Blvd, one person is confirmed deceased, several still critical. Driver is in custody," police tweeted.
The injured were taken to area hospitals.
It said the driver was undergoing several tests, including for alcohol.
Local media outlet 8 News NOW reported that the driver was a woman and that the crash occurred shortly after 6:30 pm local time between Planet Hollywood, where the Miss Universe pageant took place, and the Paris Las Vegas Hotel.
Citing a witness, it said that some men tried to stop the car.
The suspect initially left the scene, it reported.
Police would only say that an investigation was under way.
Live footage showed the usually bustling Strip taped off and closed to traffic as police examined the scene.
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