Pictures said to be from the crash scene yesterday, shared on social media, showed bloody and dismembered bodies.
The accident happened near the town of Kango, 100 kilometres from Libreville, along a stretch of the country's main highway.
"The tragic provisional toll is 18 dead," Transport Minister Ernest Mpouho Epigat said, adding that bodies of the victims had been taken to the capital.
The cause of the collision was unknown and an inquiry has been opened, the government statement said.
The government urged road users "to observe the elementary tules of road safety," especially during the current busy holiday season.
The National 1 highway, where yesterday's accident happened, links Libreville with the interior of the country and is often heavily congested.
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