The gunmen targeted the office of the Express media group, which operates the Express News channel and publishes The Express Tribune and Urdu Express newspapers.
Two guards were among the three persons injured.
Express News reported that two grenades were thrown from a flyover overlooking the office. Shots were fired from a nearby building.
The explosions damaged some parked vehicles.
No group claimed responsibility for the attack.
This was the second attack on the office in four months. In the first attack, a woman and a guard were injured when unidentified assailants opened fire.
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