A 2-2 draw with Burnley today saw United lose further ground in the table to Pep Guardiola's runaway leaders, who are 12 points clear with a game in hand.
Mourinho claimed that United's illustrious history does not guarantee them -- or any similar club -- success when faced with City's huge resources.
"When you say a club 'like Manchester United', do you think Milan is not as big as us?" said Mourinho, listing other big European clubs who are struggling domestically.
"There are many big clubs and you say big clubs, I know what is a big club. One thing is a big club and another thing is a big football team that you know is not one of the best teams in the world."
"Manchester City buy the full backs for the price of the strikers, so when you speak about big football clubs, you are speaking about the history of the club," he added.
"It is not enough, is not enough," he said. "And the price for the big clubs, the price for the big clubs is different from the other clubs.
"So the big, historical clubs are normally punished in the market for that history, so the boys are doing what they can and they are doing fine."
- United stumble -
But United's dropping of seven points in their past five games -- including conceding a last-minute equaliser at Leicester on Saturday, has left City coasting towards the league title.
"You say (we dropped) seven points from 15," said Mourinho. "I say the last two matches we had 15 chances to score and we concede three... goals and an amazing free-kick.
"So the boys do what they can, they are trying hard with the problems and injuries we have. I am not happy with the result, and against Leicester, but I am happy with my players."
United needed an injury-time equaliser from substitute Jesse Lingard -- who also scored their first -- to rescue even a point against Burnley, who had taken a 2-0 first-half lead through Ashley Barnes and Steven Defour.
"The decision that led to the goal, the lad jumps into Vokesy," said Dyche. "I don't know what he is supposed to do. In basketball that is 'charging'.
"So there is probably a mixture of feelings. And the only frustration is a couple of decisions went against us.
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