The attack followed the targeted killing of two policemen in the Malir area late last night.
A senior police official said that two men on a motorcycle flung two hand grenades at a police check post near a pedestrian bridge on Main Nursery road.
The powerful blasts injured four policemen on duty and they were taken to hospital, he said.
The blast also destroyed two motorcycles parked near the check post and damaged windows of a building in the area.
Though police and security officials claim that the graph of crime has come down in Karachi since the start of an operation last year by the police and paramilitary rangers, multiple incidents of targeted killings occur almost daily in Pakistan's financial hub which has long been plagued by political, ethnic and sectarian violence.
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