The Academy of Motion Picture Arts and Sciences has been at the receiving end of criticism since excluding black actors from the nominations last month.
Issacs took to stage to state how important diversity is in Hollywood.
"The Oscars celebrate the storytellers, who have the opportunity to work in the powerful medium of the film. And with that opportunity, comes responsibility.
"Our audiences are global and rich in diversity and every facet of the industry as well. Everyone in the Hollywood community has a role to play in bringing about the change. The Academy board of governors recently took a concrete action and sent a message to make us all stronger," she said.