In the quarters tomorrow, Advani will face Railways' Faisal Khan who bounced back from a two frame deficit to upset former Asian champion Alok Kumar 4-2.
"It's a big match of course. So far it's been a fine tournament for me and I'll hope to take the positives," Khan, who was a member of the gold medal winning Asian team that beat Pakistan last year, said.
"I'd also beaten him in the six-red snooker national in Chandigarh in 2010. But he's going great here, let's see what happens but I won't give up easily."
The holder of 12 world titles, Advani, began the day ousting Bihar's Anupam Jha with utmost ease in the last 32.
The 29-year-old returned in the evening to defeat Delhi's Sandeep Gulati when he posted breaks of 71, 62, 52 and 72 for another easy win.
Second seed Kamal Chawla snapped the dream run of unheralded Delhi youngster Avinash Kumar with an easy 4-0 win, while third seed Manan Chandra survived a scare against Shivam Arora of Bihar before posting a 4-2 win.
Meanwhile, 24-year-old Arantxa Sanchis of Maharashtra annexed the women's billiards title with a 4-1 win against an experienced Meenal Thakur of his home state.
Results (pre-QFs)
Pankaj Advani b Sundeep Gulati 72(71)-08, 93(62)-24, 91(52)-01, 80(72)-00; Dharminder Lilly b Dhwaj Haria 69-23, 61-45, 65-45, 56-50; Kamal Chawla b Avinash Kumar (DL) 63-44, 113(103)-00, 102(46)-16, 75(56)-08; Manan Chandra beat Shivam Arora 4-2 51-53, 70-54, 107(58)-24, 65-14, 09-121(121), 59-36, Faizal Khan b Alok Kumar 28-89, 51-53, 77-45, 86(43)-25, 70-20, 54-36, Shahbaaz Adil Khan b Himanshu Jain 31-61, 62-30, 76-14, 77-50, 80-39.