No one immediately claimed responsibility for the attack but the Taliban have recently staged a series of high-profile bombings ahead of the June 14 runoff in the country's presidential election.
The attack on the police base in eastern Behsud district took place late yesterday, said Ahmad Zia Abdulzai, the spokesman for the provincial governor of Nangarhar province.
A suicide car bomber first blew himself up by detonating his vehicle at the entrance to the parking lot. Two other attackers then stormed in, shooting at the security forces.
Officials are concerned there could be more violence ahead of the balloting on Saturday, though the first round of the election on April 5 passed relatively peacefully.
Last Friday, Abdullah Abdullah the front-runner in the election narrowly escaped assassination when two suicide boomers attacked his convoy during a campaign event in the capital.
At least 10 people, including three in Abdullah's entourage, were killed and dozens were wounded in the attack, which heavily damaged the front of Abdullah's armored car, destroyed several vehicles and storefronts and left the street littered with twisted metal and other rubble.
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