The five-day International AIDS Conference returns to Africa 16 years after Nelson Mandela galvanised the world to take up the fight against AIDS, describing it as "one of the greatest threats humankind has faced".
Again hosted by the coastal city of Durban, the conference is seen as the key gathering of experts tackling a pandemic that has claimed more than 30 million lives in 35 years.
Among those attending the 21st biennial conference are UN Secretary General Ban Ki-moon, activists including singer Elton John and actress Charlize Theron, and Britain's Prince Harry.
"I'm scared because I am seeing for the first time the decline in the financing from donor countries," he said.
"I cannot be dishonest with you, I need to say -- we will have a resistance, we will lose our investment, we will have to pay more later.
"If we stop now, we will certainly regret (it) because we will see a resurgence in this epidemic."
Antiretroviral drugs have allowed many sufferers to survive, but there are some 36.7 million people worldwide living with HIV/AIDS, mainly in sub-Saharan Africa.
"This conference comes at another crucial time in the HIV epidemic," said Chris Beyrer, president of the International AIDS Society.
"If we don't make the right strategic choices, we risk reversing hard-won gains. Delay is tantamount to defeat."
With no cure for the virus in sight, patients today still face lifelong reliance on the expensive antiretroviral drugs which cause side effects.
Delegates will discuss the latest scientific research amid frustration that there is still no vaccine for the stealthy virus.
"Until we effectively reach young people and get them effectively engaged, nothing is going to change in the fight," said Charlize Theron, who founded an AIDS charity working with teenagers in South Africa, her home country.
Before 2000, only wealthier countries had hosted the AIDS meeting.
That changed when South Africa became the first developing country -- and the first with an epidemic of HIV in its population -- to take the helm.
The conference was a contentious affair, but its emotional impact transformed the AIDS campaign.
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