The strikes were carried out late yesterday on the village of Susa in Deir Ezzor province, the Syrian Observatory for Human Rights said.
"Twelve civilians from a same family, including four children, were killed," Observatory head Rami Abdel Rahman told AFP.
The Britain-based monitoring organisation, which has a broad network of sources on the ground, said the strikes were likely conducted by the US-led coalition that launched air raids against IS in Syria and Iraq in 2014.
The Islamic State group has lost nearly all the territory it once held in Iraq and Syria and is clinging to a scattering of small villages and pockets of land in the border area.
The coalition admitted on Thursday to "unintentionally" killing at least 817 civilians since it started its aerial campaign against IS.
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