Scientists at the Washington University School of Medicine in St Louis say the tweets are cause for concern because young people are thought to be especially responsive to social media influences.
In addition, patterns of drug use tend to be established in a person's late teens and early 20s.
In a study published in the Journal of Medical Internet Research, the Washington University team analysed messages tweeted from May 1 through December 31, 2013, by a Twitter account called Weed Tweets@stillblazintho.
Principal investigator Patricia A Cavazos-Rehg, an assistant professor of psychiatry, counted 2,285 tweets during the eight-month study.
Of those, 82 per cent were positive about the drug, 18 per cent were either neutral or did not focus on marijuana, and 0.3 per cent expressed negative attitudes about it.
Many of the tweets were meant to be humorous. Others implied that marijuana helps a person feel good or relax, and some mentioned different ways to get high.
"These are risky ages when young people often begin experimentation with drugs," said Cavazos-Rehg.
"It's an age when people are impressionable and when substance-use behaviours can transition into addiction. In other words, it's a very risky time of life for people to be receiving messages like these," she said.
"Studies looking at media messages on traditional outlets like television, radio, billboards and magazines have shown that media messages can influence substance use and attitudes about substance use," she said.
"It's likely a young person's attitudes and behaviours may be influenced when he or she is receiving daily, ongoing messages of this sort," she added.
