Handler made the remarks while discussing Jolie and Pitt's split, which became public two days ago. It has been rumoured Pitt's alcohol and drug consumption habits are a reason for the break-up.
Handler, who is a good friend of Pitt's ex-wife Jennifer Aniston, said on her show "Chelsea" that Jolie's "lunacy" drove her husband into alleged alcohol and weed consumption.
"There are rumors that part of the problem was Brad was allegedly drinking and smoking too much weed," Handler said.
"I wonder why he needed to self-medicate. Maybe because he could have been spending the last 12 years at Lake Como hanging out with George Clooney and Matt Damon, instead of being stuck in a house with 85 kids speaking 15 different languages? Oh yeah, because he married a lunatic, that's why."
Pitt and Aniston got married in 2000 and split five years later. He soon began dating his "Mr and Mrs Smith" co-star Jolie and it was believed their closeness was responsible for Pitt's split from Aniston.
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