The former "Good Wife" actress is the first person to be cast in the drama, said The Hollywood Reporter.
The series is described as "12 Angry Men" meets podcast "Serial".
It follows a single murder trial as seen through the eyes of the individual jurors, exploring the biases and experiences that influence their judgement and how their preconceptions change along the way.
Panjabi, 43, will play Kim Dempsey, the drama's protagonist.
The character radiates quiet strength and is described as a force of nature cloaked in a professional demeanor who isn't interested in making friends but instead in finding the truth.
"CSI: Crime Scene Investigation" writer Carol Mendelsohn will executive produce.
"The Jury" is a co-production of Sony Pictures Television (where Mendelsohn is based) and ABC Studios.
The role would mark Panjabi's return to series television following her 2015 departure from CBS' "The Good Wife".
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