Youssef El-Arabi scored in the last minute of extra-time as Olympiakos knocked Arsenal out of the Europa League on Thursday on a night when four former European champions were eliminated.
Ajax, Celtic, Benfica and Porto went out but Manchester United hardly broke sweat after Simon Deli of Brugge conceded a penalty and earned a red card in the 23rd minute at Old Trafford.
Arsenal, last year's losing finalists, had won the first leg of the round of 32 tie 1-0 in Greece.
Defender Pape Abou Cisse cancelled out that advantage when he headed in a corner after 53 minutes.
Arsenal could not break through and were forced to extra time.
Pierre-Emerick Aubameyang put them back in front with a spectacular flying kick. However, in the final minute of extra time, Arsenal cleared an Olympiakos corner but were still disorganised when the ball was swung back into the area.
The cross found El Arabi free in front of goal for an unchallenged shot.
"Very hard, very tough," said Aubameyang. "Their last-minute goal was unlucky for us." At Old Trafford, Bruno Fernandes gave United the lead with a penalty after Deli's flying save.
Odion Ighalo, making his first start, hit his first goal for the club in the 34th minute.
- Tentative Ajax -
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