The ten-member Association of Southeast Asian Nations (ASEAN) hailed the project as a "milestone" in combining the economic force of a resource-rich and growing market of more than 600 million people.
The vision for the ASEAN Economic Community (AEC) is a single market with a free flow of goods, capital and skilled labour, which should help the region compete with the likes of China for foreign investment.
The new bloc "will contribute significantly to the region's growth and create developmental opportunities for all," said Vivian Balakrishnan, the foreign minister of ASEAN member Singapore.
But experts say such an idea is difficult, if not impossible, to achieve in a region marked by extremes in development levels, democratisation, and institutional capability.
The official launch of the AEC has no practical effect, and diplomats have said ASEAN - regularly criticised for a lack of concrete achievements - was keen not to miss its own deadline of 2015, set several years ago.
Research group Capital Economics said in a note the establishment of the AEC was "no game changer", and it was likely to fall short in tackling major challenges such as reducing non-tariff barriers and improving infrastructure.
"ASEAN, with its tradition of non-interference into the affairs of member countries, an absence of penalties for non-compliance, and a lack of a powerful central bureaucracy, is ill-equipped to tackle these obstacles," it said.
John Pang, a senior fellow at Singapore's S Rajaratnam School of International Studies, said there would be only "slow and incremental progress" in integrating the economies of Southeast Asia.
"The AEC will not be raising the curtain on any radical change," he wrote in a commentary.
Diplomats have conceded the single market vision is many years away, but insist the project will help change mindsets and provide momentum.
ASEAN leaders signed a declaration to establish the AEC at the group's annual summit in November but there was no official ceremony today to mark the new bloc's establishment.
Southeast Asia has already made progress on lower-hanging fruit like cutting tariffs and removing other hurdles such as clashing customs systems but significant non-tariff and other barriers remain.
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