The train, which was carrying 77 passengers and seven crew, derailed in DuPont about halfway between Tacoma and the state capital Olympia on a curve that passes over busy Interstate 5 at about 7:40 am.
Pictures from the scene showed one Amtrak train car overturned and crushed on the interstate highway and others dangling from the overpass.
Several other carriages of the 14-car train also ended up on the highway, shutting down a key section of the busy artery that connects the greater Seattle metropolitan area to Olympia. All but one car jumped the tracks.
But she cautioned that several of the roughly 100 people taken to area hospitals were in critical condition.
"We don't know if that number will change," Bova said of the death toll.
Officials gave no reason for the derailment of southbound Amtrak train 501, the inaugural run of a new service that promised faster connections between Seattle and Portland, Oregon.
Local officials had warned only weeks ago that the track still might not be safe enough to handle trains at higher speeds.
Police said five vehicles and two trucks were hit on the highway.
The National Transportation Safety Board has sent a team of experts to investigate the incident.
Chris Karnes, a local transit official who was aboard the train, told local CBS News affiliate KIRO-TV that the accident took place while it was going around a curve.
"All of a sudden, we felt this rocking and creaking noise, and it felt like we were heading down a hill," he said.
A conductor in one of the two engines on the train placed the emergency call.
"Amtrak 501, emergency emergency emergency, we are on the ground," he said, according to an audio recording of the call.
"We were coming around the corner to take the bridge over I-5 there right north of Nisqually and we went on the ground.
"We got cars everywhere and down onto the highway," he said.
Amtrak president and co-chief executive Richard Anderson said he was "deeply saddened" by the crash.
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