Aaron Finch hit an unbeaten 70 as England was trounced by eight wickets after being dismissed for only 138 at Old Trafford in the deciding fifth ODI.
Australia's 3-2 series win came after losing the last two ODIs when England looked set to build on its Ashes success.
But after winning the toss and choosing to bat, England was blown away in only 33 overs, with England captain Eoin Morgan forced to retire hurt with a concussion with the hosts at 22-3.
Starc played in the Australian domestic match last year when Phillip Hughes died after being hit by a bouncer. Morgan remained on his feet for a couple of minutes before retreating to the turf when England's medical team arrived in the middle.
It became immediately clear Morgan was groggy and unable to resume his innings and he walked slowly from the field to a round of applause from the Old Trafford crowd.
England's only resistance came from Ben Stokes (42) and Adil Rashid (35 not out). Stokes aside, England's top eight was unimpressive, with Mitch Marsh and John Hastings claiming combined bowling figures of seven for 48.
The in-form Jason Roy was given out lbw twice in the first over of the day, bowled by the recalled Starc, but after successfully overturning the first he declined to do so a second time.
Hastings added a pair of scalps with the second new ball, Hales' forgettable series ending with a half-hearted flap to a wide one outside off stump.
After the 10 powerplay overs England was 40-3, its worst return of the series in terms of both runs scored and wickets lost.
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