The 41-year-old actress will portray Meredith, an irreverent neighbour in the TV series, reported People magazine.
The new season of "Odd Mom Out," will focus on Jill's work life as she returns to her job at a fashion magazine while Andy becomes Mr Mom and realizes that parenting three kids is much harder than he expected.
Earlier this month, Barrymore and Kopelman, 38, publicly confirmed they were ending their marriage after almost four years.