Biden spoke before several hundred US airmen as drones rolled the down the runway at the Al-Dhafra Air Base, a major desert outpost near the United Arab Emirates capital, Abu Dhabi.
The Emirates is one of the most important US military and political allies in the Persian Gulf. It is also a major commercial hub that includes the business-friendly port city of Dubai.
"We have to squeeze the heart of Daesh in Iraq and Syria so they can't continue to pump their poison in the region and around the world," Biden said, using an Arabic acronym for IS, a militant group he dismissed as "criminals and cowards."
"You control the skies over Iraq and Syria and as a matter of fact, you control the skies over the whole damn world," Biden said, drawing cheers.
The Emirates is the first stop on a regional tour that will also take in Israel, the West Bank and Jordan. His wife, Jill, is accompanying him.
The trip will include talks on US economic and energy interests, as well as security concerns about Iran and Syria, the White House said.
He examined a wall in the ornate mosque bearing the 99 names of God written in Arabic before stepping outside to wave at visiting tourists kept a short distance away. Accompanying Biden on the mosque tour was its director-general, Yousif Abdallah Alobaidli, and Minister of State Reem al-Hashimi.
Biden later visited Masdar City, a government-backed clean energy campus on the capital's outskirts, taking a few moments to talk to Shefaa Mansour, a student from Baton Rouge, Louisiana, studying at the affiliated Masdar Institute.
Emirati Minister of State Sultan al-Jaber handed him a bottle of water made at the plant. The vice president looked at it, then smiled.
"Now make sure I'm still standing," he said. "Watch what happens when I take the first sip. I'm more energized." Biden then paused for a moment and added: "Do you need a partner? I'm out of a job soon."
The seven-state Emirates federation, which includes the Gulf commercial center of Dubai, is one of the largest oil producers in OPEC.
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