"The explosion happened at the gate of the Shiite mosque in the centre of Balkh district (in Balkh province)," said the provincial governor's spokesman Munir Ahmad Farhad, adding that 14 people were killed and 28 injured.
His account was confirmed by the provincial deputy police chief.
The blast came as the Islamic State group claimed responsibility for twin attacks in Kabul yesterday that also targeted Shiites, killing up to 18 people and wounding dozens.
At the same time, another attacker entered a nearby mosque and took an unspecified number of people hostage as they were commemorating Ashura, the ministry said.
The UN called the attack an "atrocity" and put the toll at 18, though the interior ministry later said it was 16.
The threat of attacks on Shiites was considered particularly serious during Ashura, and many foreign embassies in Kabul had restricted staff movements until the end of the week.
For Shiites around the world, Ashura is a symbol of the struggle against oppression.
In 2011 about 80 people were killed and more than 100 wounded when a suicide bomber struck a gathering of Shiites during Ashura in the heart of Kabul.
Grieving worshippers today described desperately trying to shelter their children against a hail of gunfire during the Kabul attacks.
One mother who gave her name as Saleha told AFP of a gunman who was "killing everyone".
"While I was hugging my little son I begged him not to kill my child," she said at a Kabul hospital.
The child survived, but she angrily denounced the Afghan government for failing to protect them.
Another witness, Ali Hussain, said attackers "indiscriminately shot everyone they faced. They wouldn't even spare women and children".
Today the Islamic State group's affiliate in Afghanistan and Pakistan claimed the Kabul attack, which President Ashraf Ghani condemned as a "clear sign of a crime against humanity".
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