A three-year trial has shown that the genetically modified potatoes can thrive despite being exposed to late onset blight. The scientists boosted resistance of potatoes to late blight without deploying fungicides.
That disease has plagued farmers for generations and it triggered the Irish potato famine in the 1840s.
Approval from the European Union is needed before commercial cultivation of this GM crop can take place.
The research is published in the journal Philosophical Transactions of the Royal Society B.
The speed with which this infection takes hold and the devastating impacts on the crop make it the number one threat to six million tonnes of potatoes produced in the UK each year, the BBC reported.
Farmers have to be continuously on their guard and need to spray up to 15 times a season to protect against blight.
As part of an EU-wide investigation into the potential for biotechnology to protect crops, scientists at the John Innes Centre and the Sainsbury Laboratory began a trial with blight-resistant potatoes in 2010.
The scientists involved say that the use of techniques to add extra genes was crucial in developing a plant resistant to the blight.
"Breeding from wild relatives is laborious and slow, and by the time a gene is successfully introduced into a cultivated variety the late blight pathogen may already have evolved the ability to overcome it," said Prof Jonathan Jones, of the Sainsbury Laboratory.
"With new insights into both the pathogen and its potato host, we can use GM technology to tip the evolutionary balance in favour of potatoes and against late blight," Jones said.
There was also a difference in yield, with the GM variety producing double the amount of tubers.
One area the scientists cannot comment on is the taste, as they were barred from eating the GM variety.
Critics of GM crops said that no matter how big the scale of the environmental benefits, they believe that consumers will not be interested.
"Is anyone really going to grow, sell or buy genetically modified potatoes?" said Liz O'Neil, director of GM Freeze.
