"The first lady of Syria has acted not as a private citizen but as a spokesperson for the Syrian presidency... [UK foreign secretary] Boris Johnson has urged other countries to do more about Syria, but the British government could say to Asma Assad, either stop using your position to defend barbaric acts, or be stripped of your citizenship," Liberal Democrat foreign affairs spokesperson, Tom Brake said.
"This is a barbarous regime, yet Asma Assad has continued to use her international profile to defend it, even after the chemical weapons atrocity," he said.
Conservative party MP Nadhim Zahawi backed the call, saying she was "very much part of the propaganda machine that is committing war crimes".
After a US strike, Asma Assad posted a message on one of her accounts saying: "The presidency of the Syrian Arab Republic affirms that what America has done is an irresponsible act that only reflects a shortsightedness, a narrow horizon, a political and military blindness to reality and a naive pursuit of a frenzied false propaganda campaign."
Social media accounts in Asma Assad's name have some 500,000 followers and are used as pro-regime tools.
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