Union leaders announced the move -- which will see pilots work only their contractual hours -- as the latest round of negotiations with airline management over pay and working hours failed.
"It is unfortunate that a year of negotiations has brought us to this point," said Chris Beebe, General Secretary of the Hong Kong Aircrew Officers Association (HKAOA).
The union represents more than 2,000 Cathay pilots and said that 92 per cent of members had approved the action.
Beebe said the union "looks forward to resuming talks with management for a fairer, more equitable agreement on pay".
A lack of pilots has led to some having to work additional shifts, reports said.
"The pilot shortage has always been serious. Some are called to work twice a month on their rostered days off," one pilot told the South China Morning Post today.
Cathay said it was "extremely disappointed" at the decision and that talks would now be put "on hold".
"We are confident that the flight crew community are aware of the high expectation from the travelling public.
"We believe they will continue to fulfil their duties and would not cause any inconvenience to passengers in the upcoming festive holidays," it said in a statement.
Germany's Lufthansa, Europe's biggest airline, was also braced for a pilots strike, with tensions heightened by its plans to expand into low-cost intercontinental services.
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