The Pentagon on Friday released the Nuclear Posture Review (NPR) in which it said that the US wants to prevent China from mistakenly concluding that any use of nuclear weapons, however limited, is acceptable.
China said that it "firmly opposed" to the NPR published by the US Department of Defence.
It is the Pentagon's first NPR since 2010.
The 74-page report cast China as "a major challenge to US interests in Asia".
The report said the US strategy for China is designed to "prevent Beijing from mistakenly concluding that it could secure an advantage through the limited use of its theatre nuclear capabilities or that any use of nuclear weapons, however limited, is acceptable".
China will resolutely stick to peaceful development and pursue a national defence policy that is defencive in nature, Ren said.
"China has adhered to the policy of no-first-use of nuclear weapons at any time and under any circumstances," he said, adding that under no circumstances will China use or threaten to use nuclear weapons against non-nuclear-weapon states or nuclear-weapon-free zones.
The US, which possesses the world's largest nuclear weapons arsenal, should conform to the irreversible world trend of peace and development rather than run in the opposite direction, state-run Xinhua news agency quoted Ren as saying.
"We hope the US side will discard its 'cold-war mentality', shoulder its own special and primary responsibility for nuclear disarmament, understand correctly China's strategic intentions and take a fair view on China's national defence and military development," he said.
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