Wu Yuliang told reporters that those speculating that the campaign was being used to target political foes were acting out of ulterior motives.
"In the past some people accused us of inaction in the face of corruption, and now that we have intensified efforts to fight corruption, we have been accused of being selective," Wu said. "I'm afraid those (critics) may have other purposes or motives."
Wu's comments came the day after a major meeting of the ruling Communist Party that renewed President Xi Jinping's drive to end corruption and tighten discipline within the 88 million-member organization that has run China since seizing power in a 1949 revolution.
More than 1 million party members have been punished in the anti-corruption campaign, which has also brought down two former top generals and a past member of the Politburo Standing Committee, the apex of political power.
"When uprooting rotten trees one has to start with the most rotten ones. If that is called selective I have to say this is just the way we do our work," said Wu, who is vice secretary of the Central Commission for Discipline Inspection.
While mainly symbolic, the move to bestow Xi with "core" status reflects his rise as the country's most powerful leader in decades, along with his determination to run the ruling party as a clean institution enjoying unfettered authority.
While this week's meeting kicked off the process of selecting new leaders, Wu and other officials at a briefing Friday said they had no information about future appointments.
Five of the current seven members of the Politburo Standing Committee all but Xi and Premier Li Keqiang are due to step down next year according to custom.
And while his assertive foreign policy has won plaudits from the public, he faces intense pressure to solve domestic challenges including slowing economic growth and massive layoffs resulting from the closure of steel mills and coal mines.
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