The United Nations health agency voiced deep concern over the outbreak that has infected some 18,000 people, including 517 who have died, since the beginning of the year.
Cholera is endemic in DR Congo, but usually only affects the east of the country.
This time however, the acute diarrhoeal infection has spread west along the Congo river and has reached Kinshasa for the first time in five years.
The capital has suffered 13 cases and two deaths since August 13, Dominique Legros, head of WHO's cholera division, told reporters in Geneva.
In a bid to stem the epidemic, Legros said WHO was sending support materials and experts to DR Congo and that it had decided today to support a large-scale vaccination campaign in Kinshasa.
In all, some 300,000 people living in the most risk-prone parts of the capital will receive the two-dose vaccine, getting the first jab between September 22 and 25 -- and the second two weeks later.
Across the country, that outbreak made 21,750 people ill and left 424 people dead.
Cholera is transmitted through contaminated drinking water and causes acute diarrhoea, with children facing a particularly high risk of infection.
There are between 1.4 and 4.3 million cases of the disease worldwide each year, and as many as 142,000 deaths, according to WHO statistics.
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