The recall covers Ram 1500 pickups from the 2005 model year.
Chrysler says in documents posted today by US safety regulators that the rear-axle pinion nut can come loose. That can cause problems that make the trucks spin out of control.
The recall comes after an investigation by the National Highway Traffic Safety Administration that began in June.
The agency found 15 complaints, including seven drivers who reported that the wheels locked at speeds over 50 miles per hour. Chrysler says there have been three crashes and one injury due to the problem.
The affected trucks were made from January 28, 2004 to August 3, 2005, according to the documents.
In one complaint to NHTSA in February 2013, a pickup driver wrote that he was on an interstate highway when the drive shaft disconnected and the truck began to spin.
"It was five seconds of terror that I thought would surely end in disaster," the driver wrote. When the truck stopped it was blocking an entrance ramp, and the driver had to drag it to the shoulder in speeding traffic, the complaint said.
Dealers will install a fix at no cost to owners. The recall will begin in February. Customers can call Chrysler at (800) 853-1403 with questions.
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